The half-life of oxycodone refers to the amount of time it takes half the drug to be eliminated from your body. The oxycodone half-life is important to understand because this is what determines how long the drug stays in a person’s system. The mean apparent elimination half-life of OxyContin is 4.5 hours, Oxycodone Hydrochloride Tablets, USP5 mg, 10 mg, 15 mg, 20 Oxycodone Hydrochloride Tablets, USP 5 mg, 10 mg, 15 mg, 20 mg and Apparent elimination half-life of oxycodone following the administration of oxycodone What is the half life of percocet 10 325 - gdc.chkme.mobi What is the half life of percocet 10 325 Mar 20, 2012. The half-life of one dose of oxycodone is an average of 3.51 hours, plus or minus 1.43 hours, according to Practical Pain Management. As Medscape explains, the half-life of a drug varies based on dosage and how it is delivered to the patient. The half-life of oxycodone, which refers to the amount of time it takes half the drug to be eliminated from your body, is about 3.2 hours; the half-life for the time-released version (OxyContin) is about 4.5 hours. It takes several half-lives to fully eliminate a drug, and everyone metabolizes medication differently depending on factors such as age, weight, genetics, and even specific health. Oxycodone have a half life of 4.5 hours. OxyContin currently is protected under patent and has no available generic. Its manufacturer Purdue Pharma claimed in their 1992 patent application that the duration of action of OxyContin, oxycodone's controlled-release preparation, is 12 hours in 90% of patients. Anyway, the half-life of Oxycodone is 3 - 4.5 hours. Read More i started tapering last week im doing 3 a day for 2 weeks then 2 a day for a week and a half and so on and im taking my doses if i feel i need it and try energy drink they are really helping me with w/d monster and amp seem to be the best for it i dont know how it works but it dose. good luck. The Percocet half-life may also be relevant because you might be wondering when withdrawal symptoms would occur. So what is Percocet’s half-life? The drug’s half-life is estimated to be 3.5 hours. However, the range varies. On average, it would take the oxycodone component of Percocet more than 19 hours to fully clear the drug from your system. The half-life of acetaminophen is. Apparent elimination half-life of Oxycodone following the administration of Oxycodone hydrochloride tablets was 3.5 to 4 hours. Specific Populations Age: Geriatric Population Oxycodone hydrochloride and acetaminophen is available in tablets for oral the plasma half life 1. Oxycodone hydrochloride controlled release tablets fdaanybody know the half life metabolism rate. to the original question, for say a urine drug test, a regular user of oxycodone or other opioids it will take 3-6 days to leave your body completely, aim for a week to be safe, the half-life of oxycodone, meaning half the drug out of your blood stream after taking a dose is roughly 3-4 hours and the high lasts around 5 hours.